Ole Gunnar Solskjaer's side looked leggy and disjointed as they lost their opening match of the 2020/21 campaign 3-1 at home to Crystal Palace.
With United playing catch-up already in the race for the top four, they can ill-afford another slip-up so early on in the season as they head to the south coast.
Brighton lost their opening game 3-1 to Chelsea at the Amex Stadium, but Graham Potter's Seagulls have won their last three games since - two in the Carabao Cup - and a 3-0 League victory at Newcastle last weekend suggests this could be a real test for the visitors.
Date, time and venue
Brighton vs Manchester United is scheduled for a 12:30pm BST kick-off on Saturday, September 26.
This match will be played behind closed doors at Amex Stadium with no fans due to be present due to government guidelines regarding coronavirus.
How to watch
TV channel: The match will be televised on BT Sport 1, with coverage starting from 11:30am.
Axel Tuanzebe and Phil Jones are out injured, while Sergio Romero is aiming to seal a move away from Old Trafford.
Aside from that trio, the real problem Solskjaer faces is a lack of match fitness among his squad.
The likes of Marcus Rashford, Anthony Martial, Mason Greenwood, Paul Pogba and Bruno Fernandes should all start at Brighton, though Solskjaer has a dilemma in other positions.
Prediction: Brighton 1-2 Man United
United go into this game as undoubted favourites, but Brighton have found some form already and will make life very difficult for their guests.
Solskjaer's men looked good on the break in their Carabao Cup win at Luton, but that 3-0 victory glossed over a sub-par performance - and they will need much better here.
Head to head (h2h) history and results
Of the six Premier League meetings between the clubs, Brighton have won twice and United four times.
United have won the last three League games in a row, including 3-0 at the Amex back in July - but before that Brighton had won their previous two home games against the Red Devils.
Betting odds and tips
- Man United to win: 4/5
- Brighton to win: 4/1
- Draw: Between 14/5 and 3/1
- Man United to win 2-1: 17/2
- Mason Greenwood to score: 9/4
Odds courtesy of Betfair Exchange. Click here to find out more.
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