The online sale, which will run from November 26 through December 10, will include the largest selection of Supreme gear ever offered by the auction house.
Christie's will notably auction off more than 230 individual skateboards, ranging from the very first set made by the streetwear brand in 1998 to sought-after Supreme collaboration pieces.
Over the years, some of the most celebrated names in contemporary art have designed boards for Supreme as part of its ongoing "Artist Series," including KAWS, Nate Lowman, Jeff Koons, Damien Hirst and Marilyn Minter.
Takashi Murakami's set of three decks is estimated to fetch between $4,000 and $6,000, while graffiti writer Rammellzee's set of two skateboards is expected to bring in between $3,000 and $5,000.
Ryan McGuiness's set of five Pantone skateboards, which is one of the first installments of Supreme's "Artist Series," is believed to sell for between $10,000 and $15,000.
"These are serious pieces of art. There's a lot to be said for putting them under glass, keeping them, and watching them appreciate. They are a crystallization of high meets low -- expository rather than assimilatory," author Bryon Hawes, who co-curated the Supreme collection offered at Christie's, said in a statement.
To stay true to the unpredictable of the streetwear brand, Christie's will also be offering a number of limited-edition Supreme collectibles such as the Stern pinball machine (estimated at $30,000 to $50,000) and a Louis Vuitton Monogram Malle Courrier 90 Trunk (estimated between $50,000 and $60,000).
In addition to the collection of Supreme, Christie's is also featuring a selection of extremely rare Hermès handbags within its "Handbags & Accessories" sale during Luxury Week New York.
The sale will be led by a matte white Himalaya Niloticus Crocodile Birkin 30 by Hermès, which the auction house describes as "the rarest handbag in the world."
The handbag, crafted from Nile crocodile hide, is expected to fetch between $40,000 and $60,000.
"It has been exciting organizing this sale to include these covetable objects alongside some of the rarest 'horseshoe' and limited-edition Hermès bags we have ever presented. This auction captures luxury as it is defined today -- from heritage brands to hype," Caitlin Donovan, who is the head of sale for "Handbags and Accessories," said in a statement.
The upcoming "Handbags X Hype" is estimated to bring in a total of $232,300 to $345,800 to Christie's.
Sotheby's held a similar auction targeting millennial buyers last February, during which the auction house offered a collection of 248 Supreme skateboard decks that was originally assembled by streetwear collector Ryan Fuller.
The complete archive was notably purchased for $800,000 by 17-year-old Canada-based collector Carson Guo, who told Artnet News that he was hoping to bridge the gap between the worlds of fine art and skate culture.