Pope Francis has spoken-out against racism and called on the United States to come together amid destruction that he said was "self-destructive and self-defeating".
Dedicating the entire English-language section of his weekly audience to the US, the pope said the 46-year-old's death was "tragic".
Pope Francis added that he was praying for all who died as a result of the "sin of racism", including Mr Floyd.
"My friends, we cannot tolerate or turn a blind eye to racism and exclusion in any form and yet claim to defend the sacredness of every human life," Francis said.
"At the same time, we have to recognise that the violence of recent nights is self-destructive and self-defeating. Nothing is gained by violence and so much is lost," he said.
The pope then asked Americans to ask God for "the national reconciliation and peace for which we yearn".