Ireland's Andrew Trimble and Ultan Dillane will both miss the final two rounds of the Six Nations Championship through injury, it was announced on Sunday.
An Irish Rugby Football Union statement confirmed that wing Trimble, who came off the bench in Ireland's 19-9 win at home to France last weekend, had broken a bone in his hand while playing for Ulster in the Celtic League.
The 32-year-old will now miss the March 10 clash against Wales in Cardiff and the final game of the Championship, against England in Dublin a week later.
"Andrew Trimble sustained a hand injury against Treviso at the Kingspan Stadium on Friday night and has been ruled out of the final two rounds of the RBS 6 Nations Championship," said the IRFU statement.
His latest injury came just after the veteran of 70 Tests had overcome a groin problem to face France.
Meanwhile, Connacht lock Dillane faces a spell on the sidelines after undergoing shoulder surgery.
"He will be ruled out of action for eight to 10 weeks," added the IRFU statement.
Ireland, however, do hope to have experienced fullback Rob Kearney back while Ulster wing Tommy Bowe has been called up to the squad.
"Rob Kearney is progressing well through his rehab of a groin injury and is expected to train fully on Monday," said the IRFU.