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Israel has warned it is on the verge of declaring a state of emergency amid fears of a new coronavirus threat that experts have warned could be the most worrying strain to emerge yet.
Prime Minister Naftali Bennett Bennett said a few cases had been reported in Israel, including at least person who had already received a vaccine booster shot.
"That doesn't mean the vaccines are no good (against the new variant). It might mean they are effective to a certain degree," said Bennett
He added: “We are currently on the verge of a state of emergency. Our main principle is to act fast, strong and now.”
There has been one confirmed case in a traveller from Malawi, and two further suspected cases, which have been put into isolation.
Israel on Friday imposed a travel ban on most African states, widening a ban announced on Thursday on the entry of foreigners from seven African countries and travel to them.
The UK has also banned travellers from six countries from entering the country, unless they are a UK or Irish resident. The EU is set to follow suit.
The variant - called B.1.1.529 - has a "very unusual constellation" of mutations, which are concerning because they could help it evade the body's immune response and make it more transmissible.
Israel has recorded 1.3 million confirmed cases of COVID-19 and more than 8,000 dead since the pandemic began.
Its vaccine rollout programme has been one of the most successful in the world with around 57% of the population of 9.4 million already fully vaccinated, according to the Health Ministry.
43.75% of the population has had a booster, according to the Our World In Data site.
A fourth wave of infections that hit Israel in June began subsiding in September. But over the past two weeks the "R", or reproduction rate of the virus, that had remained below one for two months, began climbing and has now crossed that threshold, indicating the virus could again be spreading exponentially.
Bennett told journalists a national lockdown was not an option at the moment, though Israel's coronavirus panel of experts would reconvene on Saturday night to discuss possible additional measures.
Why are experts so worried?
South African scientists say early signs from diagnostic laboratories suggest it has spread rapidly in Gauteng and may already be present in the country's other eight provinces.
The country's daily infection rate nearly doubled on Thursday to 2,465. The South Africa's National Institute for Communicable Diseases (NICD) did not attribute the resurgence to the new variant, though local scientists suspect it is the cause.
Botswana detected four cases, all foreigners who arrived on a diplomatic mission and have since left the country.
Hong Kong has one case, in a traveller from South Africa. Belgium became the first European country to confirm a case on Friday afternoon.
All viruses - including SARS-CoV-2, the virus that causes COVID-19 - change over time. Most changes have little or no impact on their properties.
However, some changes may affect how easily they spread, the their severity or the performance of vaccines against them.
This one has drawn scrutiny because it has more than 30 mutations of the spike protein that viruses use to get into human cells, UK health officials say.
That is about double the number of Delta, and makes this variant substantially different from the original coronavirus that current COVID vaccines were designed to counteract.
UK Health Security Agency Chief Medical Advisor Dr Susan Hopkins told BBC radio some mutations had not been seen before, so it was not known how they would interact with the other ones, making it the most complex variant seen so far.
So more tests will be needed to confirm if it's more transmissible, infectious or can evade vaccines.
The work will take a few weeks, the World Health Organization's technical lead on COVID-19, Maria van Kerkhove, said on Thursday. In the meantime, vaccines remain a critical tool to contain the virus.