US hospitals and clinics began vaccinating the nation's youngest children against Covid-19 on Tuesday, a milestone that was welcomed by parents eager to protect kids against the worst impacts of the virus.
Rollout of millions of shots was underway across the country, 18 months after the elderly became the first group eligible for immunization.
Children aged from six months through four years aren't at as great a risk as adults.
But the sheer level of infections has seen more than 45,000 hospitalizations and nearly 500 deaths in the 0-4 group in America since the start of the pandemic -- outcomes that vaccination could have prevented in most cases.
"We're super thrilled," said Amisha Vakil, mother of two vaccinated three-year-old boys, who wore matching Spiderman tee shirts as they got their Moderna shots at Texas Children's Hospital in Houston.
One of the twins had three open heart surgeries within his first five months.
He's super high risk so you know, we've been living in a little bubble," said Vakil. "Now he has little armor that helps a lot."
Many children being brought in Tuesday were born after the pandemic started and had only known a life of restrictions.
Anna Farrow, who came to the same hospital with her husband Luke, said she saw a new start for their son George, aged three, and Hope, aged 10 months.
"This is sort of the beginning of a regular childhood. And we're very excited about that," she said.
On the other side of the country in Needham, Massachusetts, Ellen Dietrick, an administrator at Temple Beth Shalom was preparing to welcome 300 children on the first day.
Daniel Grieneisen, the father of a three-year-old girl who got the vaccine, said: "It means that we are now just a couple weeks from being able to take her indoors places, and kind of get back to living our lives, it's pretty exciting."
Last week, a panel of experts convened by the Food and Drug Administration reviewed data from clinical trials involving thousands of children that were conducted by Pfizer and Moderna, and deemed both of the vaccines to be safe and effective.
However, a survey carried out by the Kaiser Family Foundation in May found only one-in-five parents of children under five were eager to get them vaccinated right away. A slightly higher proportion, 38 percent, said they would wait and see how well the vaccine worked for others.
In a sign of the ongoing politicization surrounding vaccines in America, Florida governor and possible Republican presidential candidate Ron DeSantis refused to place an order with the federal government for vaccines for the youngest children, leaving private practices and parents to fend for themselves.
"These are the people who have zero risk of getting anything," he said at a press conference last week.