The Champions League campaign continues to be a source of frustration for United, who were beaten in dramatic fashion on Wednesday night by Copenhagen to leave themselves bottom of Group A and facing an uphill battle to reach the knockout stages.
That made it nine defeats in 17 matches so far this season, with last weekend's last-gasp win over Fulham doing little to lift the mood as the struggle for consistency with performances and results goes on.
Luton held Liverpool to a draw last time out but a result at Old Trafford would mark their most significant result back in the top-flight.
Date, kick-off time and venue
Man United vs Luton scheduled for a 3pm GMT kick-off today, Saturday November 11, 2023.
The match will take place at Old Trafford.
Where to watch Man United vs Luton
TV channel: In the UK, the game will not be televised live due to the 3pm blackout. Highlights will be available on Match of the Day at 11pm GMT on BBC One.
Live blog: You can follow all the action this afternoon via Standard Sport’s live blog.
Man United vs Luton team news
Man United XI: Onana; Dalot, Maguire, Lindelof, Reguilon; McTominay, Eriksen; Garnacho, Fernandes, Rashford; Hojlund
Subs: Bayindir, Varane, Amrabat, Hannibal, Mainoo, Mount, Pellistri, Antony, Martial
Luton XI: Kaminsi; Kabore, Osho, Lockyer, Mengi, Dougty; Nakamba, Barkley, Townsend; Morris, Ogbene
Subs: Krul, Berry, Adebayo, Chong, Mpanzu, Clark, Brown, Giles, Nelson
Man United vs Luton prediction
It's difficult to be confident about Man United beating any team at the moment.
There were positive signs in Copenhagen before the red card, and they should be able to edge past Luton in what is unlikely to be an entertaining affair.
Man United to win, 2-0.
Head to head (h2h) history and results
Man United wins: 29
Luton wins: 4
Man United vs Luton match odds
Man United to win: 1/4
Luton to win: 7/1
Odds via Betfair (subject to change).