The pair first collaborated for "Take What You Want," which appeared in Malone's most recent and third studio album, "Hollywood's Bleeding."
While Osbourne is gearing towards the release of "Ordinary Man," the 71-year-old rocker continued to preview his twelfth studio opus with "It's a Raid."
The single is notably produced by Malone's frequent collaborator Andrew Watt, who was also on production duty in "Take What You Want."
"Mama said, ‘You can't do what you already did'/ In our revenge, by waiting for me/ So Hollywood, I've been locked up for seven days/ I'm never coming out," the musicians duet in the bridge, while Posty serves as Osbourne's backup singer during most of the song.
The former Black Sabbath frontman recently opened up about the genesis of "It's a Raid" during SiriusXM listening party and Q&A.
According to Rolling Stone, Osbourne revealed that his latest single was inspired by an incident that occured while Black Sabbath were recording "Vol. 4" in 1972.
The police swarmed into the band's Bel Air house after the vocalist accidentally triggered an alarm, prompting him to believe that it was a raid.
"It's a Raid" marks the fourth and final single off "Ordinary Man," following the previously issued "Under the Graveyard," "Straight to Hell" and the album's title track.
Malone is not not the only guest artist featured in Osbourne's much-anticipated follow-up to 2010's "Scream."
Elton John, Slash, and Rage Against the Machine's Tom Morello all contributed to the album, which was recorded in Los Angeles with Andrew Watt, Gun N' Roses' bassist Duff McKagan and the Red Hot Chili Peppers' drummer Chad Smith.
While "Ordinary Man" will arrive this Friday, February 21, Osbourne recently announced that he was cancelling his "No More Tours 2" tour dates in North America to focus on his health.
"I don't want to start a tour and then cancel shows at the last minute, as it's just not fair to the fans. I'd rather they get a refund now and when I do the North American tour down the road, everyone who bought a ticket for these shows will be the first ones in line to purchase tickets at that time," he explained in a statement.
In the meantime, discover Osbourne's latest collaboration with Post Malone, "It's a Raid," below: