The left-back has been deemed not fit enough to start at Selhurst Park, so Ben Davies, who has recovered from a knock of his own, deputises at left-back.
Ange Postecoglou had no other fresh injury concerns ahead of tonight's game in south London, with Pape Sarr available after illness and Yves Bissouma returns to the side following a one-match ban.
Richarlison remains in the front three ahead of Brennan Johnson, while the likes of Bryan Gil, Alejo Veliz and Giovani Lo Celso will all be hoping for more minutes from the bench.
"The two main ones from the other night are Pape and Destiny," Postecoglou said Thursday. "Pape is fine, he bounced back sort of 24 hours after the game. He had a bit of an illness but has trained well. Destiny we are still going to assess.
"Obviously it is a short turnaround from the other night. We'll have a look today, see how things go and make a decision after that. Everyone else has come through fine and is available."
Rodrigo Bentancur is back in full training but is unlikely to be included in the squad, with the Uruguayan targeting a November return to action, while Ryan Sessegnon remains some way off following hamstring surgery in the summer.
Asked if Sessegnon could return next month, Postecoglou said: "Nah, long-term mate, still a way to go."
Confirmed team news
Crystal Palace XI: Johnstone, Ward, Andersen, Guehi, Mitchell, Lerma, Doucoure, Hughes, Ayew, Edouard, Schlupp
Subs: Holding, Matheus Franca, Mateta, Clyne, Richards, Ahamada, Matthews, Riedewald, Rak-Sakyi
Tottenham XI: Vicario, Porro, Romero, van de Ven, Davies, Bissouma, Sarr, Kulusevski, Maddison, Richarlison, Son
Subs: Skipp, Hojbjerg, Gil Salvatierra, Emerson, Dier, Lo Celso, Forster, Johnson, Bentancur
Injuries: Bentancur, Sessegnon, Perisic, Solomon
Time and date: 8pm BST on Friday October 26, 2023
Venue: Selhurst Park