Willoughby is set to stay on as a presenter, but is continuing to take her half-term break this week.
Hammond and O’Leary usually host This Morning on Fridays, with Willoughby (and, until now, Schofield) taking the reins from Monday to Thursday.
Willoughby will return from holiday leave on 5 June.
You can follow live updates about Schofield’s This Morning departure here.
After Schofield announced his departure, Willoughby thanked her former colleague in a statement for “all of his knowledge, his experience and his humour.”
She added: “The sofa won’t feel the same without him.”
In April, Schofield was absent from This Morning due to his brother, Timothy Schofield, being on trial for child sex offences.
Schofield issued a statement on social media disowning his sibling, thanking viewers for their support and stating that he “no longer has a brother”.
On 4 April, Timothy was convicted of 11 sexual offences concerning the abuse of a teenage boy over a period of three years.