It is a particularly early stage for Spurs to enter the competition, having failed to qualify for European competition last season, and manager Ange Postecoglou has been dealt a difficult hand.
Going away to Craven Cottage is not an easy start as the Australian looks to deliver a trophy during his first season in charge.
Here’s everything you need to know.
Date, kick-off time and venue
Fulham vs Tottenham is scheduled for a 7.45pm BST kick-off time tonight, Tuesday, August 29, 2023.
Craven Cottage will host.
Where to watch Fulham vs Tottenham
TV channel and live stream: The game will not be broadcast in the UK.
LIVE coverage: Follow all the action with Standard Sport’s dedicated match blog.
Fulham vs Tottenham team news
Joao Palhinha marked his return to the starting lineup with a late goal against Arsenal and looks set to start again. Willian, however, is a doubt and Calvin Bassey will be suspended.
For Spurs, Postecoglou is confident Destiny Udogie is not injured and was only taken off against Bournemouth as a precaution. The manager has confirmed he will make changes after making minimal so far in the Premier League.
Fulham vs Tottenham prediction
A difficult task for Spurs but given their form - and Fulham’s struggles - they should have enough about them to secure a narrow win.
Spurs to win 2-1.
Head to head (h2h) history and results
Fulham wins: 18
Tottenham wins: 54
Fulham vs Tottenham latest odds
Fulham to win: 5/2
Tottenham to win: 19/20
Odds via Betfair and subject to change.