The MLS club were without their star man and evidently undercooked given their new campaign is not yet underway.
Otavio enjoyed time and space in the area to spin and fire Al-Nassr ahead inside three minutes.
Brazilian striker Talisca scored a hat-trick, capping his third goal to make it 6-0 by replicating teammate Ronaldo's trademark 'Siu' celebration.
— DAZN Football (@DAZNFootball) February 1, 2024
Former Manchester City Aymeric Laporte got on the scoresheet as the Saudi Arabian side leapt into a three-goal lead after 12 minutes. Mohammed Maran also notched.
A packed house in Riyadh was forced to wait until the 83rd minute for Messi to appear as a substitute.
The Argentine had played 88 minutes in Inter's 4-3 defeat to Al-Hilal on Monday and his minutes are evidently being managed as part of his pre-season programme, amid worries over his hamstring. Whether he would have started had Ronaldo been on the pitch remains unknown.
Inter round off their preparations for the new season with a tour of Asia, where they will play a Hong Kong XI and Japan's Vissel Kobe, before Messi takes on boyhood club Newell's Old Boys in Miami on February 16.
Ronaldo's Al-Nassr face rivals Al-Hilal in a friendly next week ahead of their AFC Champions League knockout tie with Saudi team Al Feiha on February 14.