The Reds will be looking to consolidate after their positive start to the group last week, a 1-0 win over Ajax in Amsterdam.
Jurgen Klopp’s side got back to winning ways in the Premier League at the weekend too with goals from Roberto Firmino and Diogo Jota seeing them past Sheffield United.
Two wins from two in the group would give the 2019 champions just the start they were looking for as they bid to progress as group winners.
Here’s everything you need to know ahead of the match.
What time is the game?
The match kicks off at 8pm on Tuesday 26 October at Anfield.
Where can I watch it?
The game will be shown live on BT Sport 3 and BT Sport Ultimate. Subscribers can also watch via the BT Sport website and app.
Joel Matip, Naby Keita and Thiago Alcantara are fit in time for the clash.
Defender Matip has been out since sustaining a knock in the Merseyside derby on October 17 while Thiago (knee) was injured towards the end of the game at Goodison Park and fellow midfielder Keita - back in training after testing negative for coronavirus - has not played since coming off at half-time in the 7-2 hammering by Aston Villa just before the international break.
With Matip out, as well as long-term absentee Virgin Van Dijk (knee), midfielder Fabinho will continue to deputise in central defence.
Liverpool XI: Alisson; Alexander-Arnold, Fabinho, Gomez, Robertson; Milner, Henderson, Shaqiri; Minamino, Origi, Diogo Jota.
Midtjylland XI: Andersen; Andersson, Sviatchenko, Scholz, Paulinho; Onyeka, Cajuste; Dreyer, Sisto, Mabil; Kaba
FC Midtjylland: 22/1
Liverpool haven’t been quite their free-scoring selves so far this season but they should have more than enough to get all three points tonight. Liverpool 4-0 FC Midtjylland