The England international missed Wednesday's dramatic six-goal draw away at Galatasaray in the Champions League due to a one-game European suspension that followed his controversial sending off in Copenhagen.
Rashford returns tonight, but Rasmus Hojlund is only on the bench after returning from injury in Istanbul, having sat out the 3-0 win at Everton last weekend. Anthony Martial is back in up front.
Despite goalkeeper Andre Onana’s struggles, he retains his starting place ahead of back-up Altay Bayindir.
Christian Eriksen, Casemiro and Lisandro Martinez are longer-term absentees, while Mason Mount is suffering from a calf injury as his frustrating start to life as a United player continues. Tyrell Malacia has suffered a setback in training.
Jonny Evans is also ruled out along with Malacia, with Luke Shaw surprisingly starting alongside Harry Maguire at centre-back with both Victor Lindelof and Raphael Varane on the bench.
Erik ten Hag turns back to young Kobbie Mainoo, too. Praised for his performance at Goodison Park, the midfielder started on the bench for the draw in Turkey earlier this week. Jadon Sancho is still unavailable, meanwhile.
United are a point ahead of Newcastle and are in decent form in a Premier League context, though have struggled against the more competitive sides this season.
A defeat on the road would pile more pressure on Ten Hag, with chances of Champions League progression looking very slim heading into the final matchday.
Man Utd XI: Onana, Wan-Bissaka, Maguire, Shaw, Dalot, McTominay, Mainoo, Rashford, Bruno Fernandes, Garnacho, Martial
Subs: Bayindir, Lindelof, Amrabat, Hojlund, Reguilon, Varane, Antony, Pellistri, Van de Beek
Injured: Eriksen, Casemiro, Martinez, Mount, Evans, Malacia, Diallo
Date and time: 8pm GMT on Saturday December 2, 2023
Venue: St James’ Park