The Bees did the double over the treble winners last season but things have changed since.
Not only are Thomas Frank’s side struggling to scale previous heights, Man City are now in ominous form once again.
Unbeaten in their last seven matches and having recovered key players in Kevin De Bruyne and Erling Haaland of late, things now feel like they’re clicking.
Here’s how to watch all the action this evening.
Where to watch Brentford vs Man City
TV channel: The game will be broadcast live in the UK on Sky Sports Main Event, Sky Sports Premier League and Sky Sports Ultra HDR. Coverage of Monday Night Football begins at 6:30pm GMT, with the game then starting at 8pm.
Live stream: Subscribers will also be able to watch on a live stream online via the Sky Go app.
LIVE coverage: Follow all the action LIVE tonight with Standard Sport’s dedicated match blog.