Like their opponents, the Pharos are yet to win a game at this year's AFCON, enduring something of a nightmare tournament having reached the final two years ago.
Without Mohamed Salah until the latter stages, should they even get there, it has been an underwhelming few weeks for Egypt. An exit at this early stage would have to be seen as a disaster.
Still, they will fancy their chances the Leopards. DR Congo have only tasted victory in one knockout game since way back in 1998.
Here's how to follow all the action.
Where to watch Egypt vs DR Congo
TV channel: In the UK, the game will be televised live on Sky Sports Football, with coverage starting at 7.55pm GMT before kick-off at 8pm.
Live stream: Subscribers can also catch the contest live online via the Sky Go app.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog.