Nzalang Nacional came out on top in a group also containing powerhouses Nigeria and hosts Ivory Coast, continuing their excellent record of reaching this stage in all four of their tournament appearances. Momentum certainly feels with them.
Guinea, meanwhile, have lost all six of their knockout games at the AFCON since reaching the final way back in 1976. They are now out to avoid that curse continuing.
Here's how to watch all the action this afternoon.
Where to watch Equatorial Guinea vs Guinea
TV channel: In the UK, the game will be televised live on Sky Sports Football, with coverage starting at 4:55pm GMT before a 5pm kick-off.
Live stream: Subscribers can also catch the contest live online via the Sky Go app.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog.