Curtis Jones and Cody Gakpo scored quickfire goals at Anfield earlier this month to make the Reds favourites to reach Wembley in February after Willian had given the Cottagers the lead.
Still, Marco Silva’s side have caused Liverpool more than a few problems this season and will not go down without a fight, even though they are up against it.
Here’s everything you need to know about where to watch the game.
Where to watch Fulham vs Liverpool
TV channel: The game will be broadcast on Sky Sports Main Event, Sky Sports Football and Sky Sports Ultra HDR. Coverage starts at 7pm GMT ahead of an 8pm kick-off.
Live stream: Subscribers will be able to watch on a live stream via the Sky Go app.
Live blog: Follow all the action with Standard Sport’s dedicated match blog.