After a draw between these two teams on the opening weekend of the season, their respective campaigns have diverged significantly since, with the Reds sitting pretty in first place while making a convincing challenge for as many as four trophies.
Chelsea will stand between the outgoing Jurgen Klopp and one piece of silverware, the Carabao Cup, in a Wembley final next month but for now the league is both clubs' centre of attention.
A win for the Blues would put them within touching distance of the European places but also come as a major shock, as their away form has been pretty dire of late and Liverpool have not lost on home soil this season.
Where to watch Liverpool vs Chelsea
TV channel: In the UK, tonight's game will be televised live on TNT Sports 1 and Ultimate. Coverage starts at 7:30pm GMT ahead of an 8:15pm kick-off.
Live stream: Subscribers can also catch the contest live online via the Discovery+ app and website.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog, with expert analysis from Nizaar Kinsella at Anfield.