Erik ten Hag’s side have been hugely inconsistent so far this season and a defeat at Rodney Parade would see yet more serious questions asked, as well as leave his side without any hope of major silverware this term.
While the Welsh side have produced their fair share of cup upsets over the years, anything other than a convincing Man Utd win here over fourth-tier opposition would hardly inspire much confidence in the Dutchman.
Here’s everything you need to know about where to watch the game.
Where to watch Newport vs Man Utd
TV channel: Today's contest will be broadcast live and free-to-air on BBC One, with coverage starting at 4pm GMT ahead of a 4:30pm kick-off.
Live stream: The BBC Sport website and BBC iPlayer will offer a live stream service online for free via their app and website.
Live blog: Follow all the action this afternoon with Standard Sport’s dedicated match blog.