The Super Eagles are out to avoid the same fate they suffered at AFCON two years ago, when a promising group stage was cast aside by a hugely disappointing performance as they departed in the last-16.
In fact, it was Cameroon who they beat at this stage in the 2019 Cup of Nations.
The Indomitable Lions are out to gain revenge for the heartbreak of that second-half comeback.
But it was a far-from easy run through the groups for Rigobert Song's side, as they relied on late drama against Gambia to qualify amid intense speculation over their off-field issues and the status of Manchester United goalkeeper Andre Onana.
Where to watch Nigeria vs Cameroon
TV channel: In the UK, the game will be televised live on BBC Three and Sky Sports Football, with kick-off at 8pm GMT.
Live stream: The game will be aired live and free online via the BBC Sport and iPlayer portals. Sky subscribers can also catch the contest via the Sky Go app.
Live blog: You can follow all the action on matchday via Standard Sport’s live blog.