Manchester United will attempt to cut Manchester City's eight-point lead at the top of the table in a massive derby match between the top two teams in the table.
However they will be without the influential Paul Pogba, who is suspended.
Marouane Fellaini is a doubt, although Nemanja Matic will play despite sustaining a slight knock this week.
Pep Guardiola will meanwhile make a late decision on Vincent Kompany but Fabian Delph is unlikely to play after illness.
Follow all of the live action below.
What time does it start?
The game kicks-off at 16.30.
Where can I watch it?
The game will be live on Sky Sports. Subscribers can also watch the match on the SkyGo app.
What are the odds?