The Blades have fallen off the pace in the Premier League and a European finish for themselves no longer appears likely.
Jose Mourinho’s side have been solid since the restart, though, and a win will put them back to within four points of Manchester United and Wolves.
The Spurs boss has seen several players begin to play with more consistency and end product in this part of the season, which will form part of his plans for next season’s rebuild.
Here’s everything you need to know ahead of kick-off.
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Confirmed line-ups and team news
Sheffield United: Henderson, Basham, Egan, Robinson, Baldock, Stevens, Norwood, Berge, Osborn, McGoldrick, McBurnie. Subs: Jagielka, Zivkovic, Mousset, Moore, K Freeman, Rodwell, Sharp.
Tottenham: Lloris, Aurier, Dier, Sanchez, Davies, Sissoko, Lo Celso, Bergwijn, Lucas, Son, Kane. Subs: Gazzaniga, Alderweireld, Vertonghen, Winks, Skipp, Gedson, Ndombele, Dele, Lamela.
John Lundstram misses out for the Blades with a shoulder injury while John Fleck and Luke Freeman are also missing through injury. Sander Berge and Ben Osborn come into the side.
Juan Foyth and Japhet Tanganga remain out for Jose Mourinho’s side.
When is it and what time is kick-off?
The match will begin at 6pm on Thursday 2 July at Bramall Lane.
How can I watch it online and on TV?
The match will be broadcast live on Sky Sports Premier League, Sky Sports Main Event and Sky Sports Ultra HD.
If you’re not a Sky customer you can grab a NOWTV Day Pass here to watch without a subscription.
Sheffield United: 13/4