Uber driver blocked roads leading from European institutions to central Brussels on Thursday (November 25).
They were protesting against a court ruling which will see their activities stopped in the Belgian capital from Friday (November 26) evening.
The Brussels Appeals Court ruled that a 2015 ban on private individuals offering taxi services also applied to professional drivers.
Uber said it would stop its operations in Brussels from 1800 local time Friday.
Shah Sayed is an Uber driver.
"The situation is catastrophic. We find ourselves without jobs, with no income, we've all got families and bills to pay."
Uber said the court's ruling would affect around 2,000 drivers.
The U.S. firm urged Belgian authorities to quickly change taxi service laws.